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CEP-1347

Chemical Structure : CEP-1347

CAS No.: 156177-65-0

CEP-1347 (KT-7515;KT 7515;CEP 1347)

Catalog No.: PC-70174Not For Human Use, Lab Use Only.

CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.

    Parkinson Disease

    Phase 2 Discontinued

    Physicochemical Properties

    M.Wt 615.76
    Formula C33H33N3O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl (5R,7R,8S)-2,11-bis((ethylthio)methyl)-7-hydroxy-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylate

    References

    1. Kaneko M, et al. J Med Chem. 1997 Jun 6;40(12):1863-9.

    2. Maroney AC, et al. J Neurosci. 1998 Jan 1;18(1):104-11.

    3. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8.

    4. Eggert D, et al. J Immunol. 2010 Jan 15;184(2):746-56.

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