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Chemical Structure : CEP-1347
Catalog No.: PC-70174Not For Human Use, Lab Use Only.
CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
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CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
CEP-1347 has weak inhibitory activity for Trk A and MLCK.
CEP-1347 promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade.
CEP-1347 inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells.
CEP-1347 elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.
| M.Wt | 615.76 | |
| Formula | C33H33N3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaneko M, et al. J Med Chem. 1997 Jun 6;40(12):1863-9.
2. Maroney AC, et al. J Neurosci. 1998 Jan 1;18(1):104-11.
3. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8.
4. Eggert D, et al. J Immunol. 2010 Jan 15;184(2):746-56.
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