Chemical Structure : CK-586
CAS No.:
2830607-59-3
CK-586
(CK-4021586, CK586)
Catalog No.: PC-22762Not For Human Use, Lab Use Only.
CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
CK-586 is a partial inhibitor of cardiac myofibrillar ATPase activity (EC50=2.9 µM) that requires the regulatory light chain.
In preclinical models, CK-586 reduced cardiac hypercontractility by decreasing the number of active myosin cross-bridges during cardiac contraction thereby reducing the contractile force, without effect on calcium transients.
Physicochemical Properties
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M.Wt
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405.45
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Formula
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C21H25F2N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,5,8-Triazaspiro[3.5]nonane-2-carboxaldehyde, 5-[(3,4-difluorophenyl)methyl]-8-(trans-4-methylcyclohexyl)-6,9-dioxo-
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References
1. Victor N Rivas, et al. Sci Rep. 2024 May 27;14(1):12038.
2. Saswata Sankar Sarkar, et al. Biophys J, VOLUME 122, ISSUE 3, SUPPLEMENT 1, 122A, FEBRUARY 10, 2023
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