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Chemical Structure : CK-586
Catalog No.: PC-22762Not For Human Use, Lab Use Only.
CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
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CK-4021586 (CK-586) is a potent, selective and oral cardiac myosin inhibitor, inhibits the ATPase activity of two-headed heavy meromyosin (HMM) but not single-headed subfragment-1.
CK-586 is a partial inhibitor of cardiac myofibrillar ATPase activity (EC50=2.9 µM) that requires the regulatory light chain.
In preclinical models, CK-586 reduced cardiac hypercontractility by decreasing the number of active myosin cross-bridges during cardiac contraction thereby reducing the contractile force, without effect on calcium transients.
| M.Wt | 405.45 | |
| Formula | C21H25F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Victor N Rivas, et al. Sci Rep. 2024 May 27;14(1):12038.
2. Saswata Sankar Sarkar, et al. Biophys J, VOLUME 122, ISSUE 3, SUPPLEMENT 1, 122A, FEBRUARY 10, 2023
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