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Chemical Structure : CK 666
CAS No.: 442633-00-3
Catalog No.: PC-62458Not For Human Use, Lab Use Only.
CK-666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CK-666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM).
CK-666 reduces actin polymerization around intracellular Listeria to background levels at lower concentrations than CK-636.
CK-666 alters the morphology and slightly slowed but did not stop the gliding motility of fish keratocytes
| M.Wt | 296.345 | |
| Formula | C18H17FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide |
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1. Hetrick B, et al. Chem Biol. 2013 May 23;20(5):701-12.
2. Nolen BJ, et al. Nature. 2009 Aug 20;460(7258):1031-4.
3. Yi K, et al. Nat Cell Biol. 2011 Aug 28;13(10):1252-8.
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