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CNP-520

Chemical Structure : CNP-520

CAS No.: 1387560-01-1

CNP-520 (Umibecestat, CNP520)

Catalog No.: PC-60085Not For Human Use, Lab Use Only.

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Umibecestat (CNP520) is a potent, selective, and efficacious β-Secretase (BACE1) inhibitor with IC50 of 11 nM and 30 nM for BACE1 and BACE2, respectively.
Umibecestat (CNP520) reduced significantly Aβ levels in mice and rats in acute and chronic treatment regimens without any side effects.

Physicochemical Properties

M.Wt 513.801
Formula C19H15ClF7N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)picolinamide

References

1. Neumann U, et al. EMBO Mol Med. 2018 Sep 17. pii: e9316. doi: 10.15252/emmm.201809316.

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