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Chemical Structure : COH-29
CAS No.: 1190932-38-7
Catalog No.: PC-45751Not For Human Use, Lab Use Only.
A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM; overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel; inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells; reduced tumor growth in mouse xenograft models of human cancer.
| M.Wt | 420.4378 | |
| Formula | C22H16N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzamide,N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy- |
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1. Zhou B, et al. Cancer Res. 2013 Nov 1;73(21):6484-93.
2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.
3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.
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