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CP-466722

Chemical Structure : CP-466722

CAS No.: 1080622-86-1

CP-466722 (CP466722;CP 466722)

Catalog No.: PC-42778Not For Human Use, Lab Use Only.

CP-466722 is a poten and selective ATM inhibitor (IC50=0.41 uM) without effect on ATR kinase, does not inhibit PI3K, PI3K-like protein kinases or Abl kinase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CP-466722 is a poten and selective ATM inhibitor (IC50=0.41 uM) without effect on ATR kinase, does not inhibit PI3K, PI3K-like protein kinases or Abl kinase.
CP-466722 disrupts ATM-dependent cell cycle checkpoints in cells.

Physicochemical Properties

M.Wt 349.3467
Formula C17H15N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 7 mg/mL (Need warming)

Chemical Name/SMILES

1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-

References

1. Rainey MD, et al. Cancer Res. 2008 Sep 15;68(18):7466-74.

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