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Chemical Structure : CRBN(BRAF)-24
Catalog No.: PC-38718Not For Human Use, Lab Use Only.
CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells.
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CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells.
CRBN(BRAF)-24 showed more potent and sustained suppression of MAPK signaling than a BRAFV600E inhibitor, PLX-8394, in BRAFV600E-driven cancer cells.
CRBN(BRAF)-24 induced neither BRAFWT degradation nor paradoxical activation of the MAPK pathway in BRAF wild-type cells.
| M.Wt | 1111.168 | |
| Formula | C53H57F3N12O10S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nobumichi Ohoka, et al. Cancer Sci. 2022 May 17. doi: 10.1111/cas.15401.
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