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Chemical Structure : CRS-3123
Catalog No.: PC-61436Not For Human Use, Lab Use Only.
A novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
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A novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI); inhibits de novo toxin production in high cell density, stationary phase cultures of C. difficile at 1 mg/L; demonstrates efficacy in the hamster model of CDI and is superior to vancomycin 0.5 mg/kg in CDI model.
Bacterial Infection
Phase 1 Clinical
| M.Wt | 515.264 | |
| Formula | C19H21Br2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Citron DM, et al. J Antimicrob Chemother. 2009 May;63(5):972-6.
2. Ochsner UA, et al. J Antimicrob Chemother. 2009 May;63(5):964-71.
3. Critchley IA, et al. J Antimicrob Chemother. 2009 May;63(5):954-63.
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