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Chemical Structure : CRT-0105446
Catalog No.: PC-70100Not For Human Use, Lab Use Only.
CRT-0105446 (CRT0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.
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CRT-0105446 (CRT0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.
CRT-0105446 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
CRT-0105446 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);
| M.Wt | 421.438 | |
| Formula | C20H18F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.
2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.
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