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CRT-0105446

Chemical Structure : CRT-0105446

CAS No.: 1661846-05-4

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CRT-0105446 (CRT0105446)

Catalog No.: PC-70100Not For Human Use, Lab Use Only.

CRT-0105446 (CRT0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRT-0105446 (CRT0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.
    CRT-0105446 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
    CRT-0105446 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);

    Physicochemical Properties

    M.Wt 421.438
    Formula C20H18F3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(3-(4-methoxy-2-(trifluoromethyl)phenyl)pyridin-4-yl)thiazol-2-yl)isobutyramide

    References

    1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.

    2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.

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