Chemical Structure : CS12192
CAS No.:
1888318-68-0
CS12192
(CS 12192)
Catalog No.: PC-22634Not For Human Use, Lab Use Only.
CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively.
CS12192 inhibits Flt4 with IC50 of 107 nM, weakly inhibits JAK2 with an IC50 of 1404 nM.
CS12192 shows slightly over 50% of inhibitory activity only to a few other kinases (such as BMX, FLT3, KDR, but not TYK2) in an activity screening assay for a panel of 75 human kinases.
CS12192 inhibits IL-2 stimulation induced a clear phosphorylation of STAT1, 3, and 5 in KHYG-1 cell line.
CS12192 is a selective inhibitor against JAK3/JAK1, but not JAK2.
CS12192 suppresses IFN gene expression through the inhibition of TBK1 signaling pathway.
CS12192 (80 mg/kg) ameliorates disease severity of both AIA and CIA in rats.
Physicochemical Properties
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M.Wt
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507.95
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Formula
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C25H23ClFN7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-((5-chloro-2-((4-fluoro-3-(N-methylacrylamido)phenyl)amino)pyrimidin-4-yl)amino)propyl)-4-cyanobenzamide
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References
1. Shan S, et al. Int Immunopharmacol. 2019 Dec;77:105914.
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