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Chemical Structure : CTN06
Catalog No.: PC-35180Not For Human Use, Lab Use Only.
CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.
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CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively; weakly inhibits Itk (IC50=0.5 uM), and shows no inhibition on Src (IC50=5 uM) and Mer (IC50=10 uM); effectively kills PC3 and other prostate cancer cells, induces autophagy as well as apoptosis in prostate cancer cells; inhibits the phosphorylation of Btk, Etk and the downstream signal PLCγ2, Stat3, Akt in prostate cancer cells; inhibits PC3 xenograft tumor growth in vivo.
| M.Wt | 563.706 | |
| Formula | C33H37N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo W, et al. Cell Death Dis. 2014 Sep 4;5:e1409.
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