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Chemical Structure : CU-CPT22
CAS No.: 1416324-85-0
Catalog No.: PC-38135Not For Human Use, Lab Use Only.
CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells).
CU-CPT22 preferentially inhibits TLR2/1 signaling, without affecting a panel of homologous TLRs (TLR2/6, TLR3, TLR4, and TLR7).
CU-CPT22 competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with high inhibitory activity and specificity.
CU-CPT22 demonstrated minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4).
CU-CPT22 also inhibits the downstream signaling transduction in cellular assays, inhibits TNF-α (60%) and IL-1β (95%) at 8 uM in the Pam3CSK4-activated RAW 264.7 cells.
CU-CPT22 reduced the nuclear translocation of NF-κB and secretion of TNF-α from cultured primary mouse microglia.
CU-CPT22 also inhibits the downstream signaling transduction in cellular assays, inhibits TNF-α (60%) and IL-1β (95%) at 8 uM in the Pam3CSK4-activated RAW 264.7 cells.
| M.Wt | 362.378 | |
| Formula | C19H22O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Hexyl 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate |
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1. Cheng K, et al. Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12246-9.
2. Daniele SG, et al. Sci Signal. 2015 May 12;8(376):ra45.
3. Bock S, et al. Pharmacol Res. 2016 Mar;105:44-53.
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