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Chemical Structure : CVM-6-139-1
Catalog No.: PC-73291Not For Human Use, Lab Use Only.
CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.
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CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.
CVM-6-139-1 blocks p-HIPK2 [S359/T360] in primary spinal motor neurons and protected >60% of these neurons from tunicamycin- and SOD1G93A-induced cell death.
CVM-6-139-1 attenuates TDP-43 proteinopathy-induced cell death in HEK293 cells and spinal motor neurons.
CVM-6-139-1 protects neurons from cell death induced by either wild type or mutant TDP-43.
| M.Wt | 383.426 | |
| Formula | C18H17N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.
2. Miduturu CV et al. Chem Biol. 2011;18:868–879.
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