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CX-4945

Chemical Structure : CX-4945

CAS No.: 1009820-21-6

CX-4945 (Silmitasertib;CX4945)

Catalog No.: PC-45870Not For Human Use, Lab Use Only.

CX-4945 (Silmitasertib, CX4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.

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Biological Activity

CX-4945 (Silmitasertib, CX4945) is a potent, selective, orally bioavailable, ATP-competitive inhibitor of protein kinase Casein Kinase 2 (CK2) with Ki of 0.38 nM, CK2α IC50 of 1 nM.
CX-4945 (Silmitasertib) displays good selectivity profile against a panel of 238 kinases.
CX-4945 (Silmitasertib)  attenuates PI3K/Akt signaling, blocks CK2-dependent HIF-1α transcription, caused cell cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells.
CX-4945 (Silmitasertib)  exhibits antitumor efficacy in murine xenograft models.

Physicochemical Properties

M.Wt 349.7705
Formula C19H12ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-

References

1. Pierre F, et al. J Med Chem. 2011 Jan 27;54(2):635-54.

2. Siddiqui-Jain A, et al. Cancer Res. 2010 Dec 15;70(24):10288-98.

3. Siddiqui-Jain A, et al. Mol Cancer Ther. 2012 Apr;11(4):994-1005.

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