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CYT387

Chemical Structure : CYT387

CAS No.: 1056634-68-4

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CYT387 (CYT-387, Momelotinib)

Catalog No.: PC-42751Not For Human Use, Lab Use Only.

Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
Momelotinib (CYT387) shows significantly less activity against other kinases, including JAK3 (IC50=155 nM).
Momelotinib (CYT387) inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM.
Momelotinib (CYT387) inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).

Physicochemical Properties

M.Wt 414.4598
Formula C23H22N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 40 mg/mL
Chemical Name/SMILES

Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-

References

1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.

2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.

3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.

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