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Chemical Structure : Calmodulin inhibitor W-7
CAS No.: 61714-27-0
Catalog No.: PC-23469Not For Human Use, Lab Use Only.
W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively.
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|---|---|---|---|
| 10 mg | $68 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
| 250 mg | Get quote |
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W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively.
W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle.
Treatment with W-7 results in the dose-dependent inhibition of cell proliferation in various human multiple myeloma cell lines.
W-7 induces G1 phase cell cycle arrest by downregulating cyclins and upregulating p21cip1. W-7 induces apoptosis via caspase activation.
| M.Wt | 377.32 | |
| Formula | C16H22Cl2N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(6-Aminohexyl)-5-chloronaphthalene-1-sulfonamide hydrochloride |
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1. H Hidaka, et al. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4354-7.
2. M Asano. J Pharmacol Exp Ther. 1989 Nov;251(2):764-73.
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