Calycosin | PANoptosis inhibitor | Probechem Biochemicals

Chemical Structure : Calycosin

CAS No.: 20575-57-9

Calycosin (Cyclosin)

Catalog No.: PC-24316Not For Human Use, Lab Use Only.

Calycosin is a flavonoid compound derived from the root of Astragalus, alleviates ischemic stroke by inhibiting PANoptosis.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
50 mg	$278	In stock
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Biological Activity

Calycosin is a flavonoid compound derived from the root of Astragalus, alleviates ischemic stroke by inhibiting PANoptosis.
Calycosin has significant effects in various biological activities, including anti-inflammatory, antioxidation, antitumor, improving cardiovascular health, regulating metabolism, and enhancing immune function, especially in the nervous system.
Calycosin could improve the cell growth of HT22, leading to enhanced cell viability, reduced lactate dehydrogenase leakage, and decreased cell apoptosis after OGD/R.
Calycosin also regulates the expression of PANoptosis-related genes such as NLRP3, GSDMD, MLKL, and RIPK1 and increases the Bcl-2/Bax ratio, effectively reducing cellular damage and providing protection.
PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis.

Physicochemical Properties

M.Wt	284.27
Formula	C16H12O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one

References

1. Huiyan An, et al. ACS Chem Neurosci. 2025 Mar 29. doi: 10.1021/acschemneuro.5c00072.

2. Zhou Y, et al. Tumour Biol. 2015 Feb 12.

Calycosin (Cyclosin)

Biological Activity

Physicochemical Properties

References

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