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Cediranib

Chemical Structure : Cediranib

CAS No.: 288383-20-0

Cediranib (AZD2171;AZD 2171;AZD-2171)

Catalog No.: PC-42450Not For Human Use, Lab Use Only.

Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
Cediranib (AZD2171) also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR.
Cediranib (AZD2171) inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells.
Cediranib (AZD2171) inhibits angiogenesis, neovascular survival and tumor growth in vivo.

Physicochemical Properties

M.Wt 450.5053
Formula C25H27FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 49 mg/mL

Chemical Name/SMILES

Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-

References

1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.

2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.

3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.

4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.

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