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Chemical Structure : Corin
CAS No.: 1808113-09-8
Catalog No.: PC-62518Not For Human Use, Lab Use Only.
Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 25 mg | $958 | In stock | |
| 100 mg | Get quote |
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Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat; exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes; demonstrates effectivity in slowing tumor growth in a melanoma mouse xenograft model.
| M.Wt | 428.536 | |
| Formula | C26H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-((4-(2-aminocyclopropyl)phenyl)amino)-4-oxobutyl)-N-(2-aminophenyl)benzamide |
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1. Kalin JH, et al. Nat Commun. 2018 Jan 4;9(1):53.
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