Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DDD489
Catalog No.: PC-23267Not For Human Use, Lab Use Only.
DDD489 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 0.85 uM, and C. parvum EC50 of 0.04 uM, shows anti-cryptosporidials activity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DDD489 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 0.85 uM, and C. parvum EC50 of 0.04 uM, shows anti-cryptosporidials activity.
DDD489 is selective over HsKRS (IC50=22 uM) and shows low cytotoxicity in HsHepG2 cells.
DDD489 is effective in key cryptosporidiosis mouse models.
DDD489 (15 mg/kg, BID) reduce parasite shedding and diarrheal scores in calves.
Overexpression or mutation of CpKRS (A309L mutation) confers resistance to DDD489.
DDD489 binds in a similar pose in the ATP site of CpKRS.
| M.Wt | 382.31 | |
| Formula | C15H16F6N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Caldwell N, et al. Sci Transl Med. 2024 Oct 23;16(770):eadm8631.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
