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Chemical Structure : DDD508
Catalog No.: PC-23268Not For Human Use, Lab Use Only.
DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.
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DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.
DDD508 is selective over HsKRS (IC50=10 uM) and shows low cytotoxicity in HsHepG2 cells.
DDD508 is effective in key cryptosporidiosis mouse models.
DDD508 (15 mg/kg, BID) reduce parasite shedding and diarrheal scores in calves.
Overexpression or mutation of CpKRS (A309L mutation) confers resistance to DDD508.
DDD508 binds in a similar pose in the ATP site of CpKRS.
| M.Wt | 317.34 | |
| Formula | C17H19NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Caldwell N, et al. Sci Transl Med. 2024 Oct 23;16(770):eadm8631.
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