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DDD508

Chemical Structure : DDD508

CAS No.: 2170696-45-2

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DDD508 (DDD-508)

Catalog No.: PC-23268Not For Human Use, Lab Use Only.

DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity.
DDD508 is selective over HsKRS (IC50=10 uM) and shows low cytotoxicity in HsHepG2 cells.
DDD508 is effective in key cryptosporidiosis mouse models.
DDD508 (15 mg/kg, BID) reduce parasite shedding and diarrheal scores in calves.
Overexpression or mutation of CpKRS (A309L mutation) confers resistance to DDD508.
DDD508 binds in a similar pose in the ATP site of CpKRS.

Physicochemical Properties

M.Wt 317.34
Formula C17H19NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-hydroxy-N-((1-hydroxycyclohexyl)methyl)-4-oxo-4H-chromene-2-carboxamide

References

1. Caldwell N, et al. Sci Transl Med. 2024 Oct 23;16(770):eadm8631.

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