Chemical Structure : DDL-357
CAS No.:
3077900-08-1
DDL-357
(DDL357)
Catalog No.: PC-24532Not For Human Use, Lab Use Only.
DDL-357 is a small molecule secreted isoform of clusterin (sCLU) enhancer with EC50 of 223 nM, increases brain sCLU in the murine ApoE4TR-5XFAD model of AD.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDL-357 is a small molecule secreted isoform of clusterin (sCLU) enhancer with EC50 of 223 nM, increases brain sCLU in the murine ApoE4TR-5XFAD model of AD.
DDL-357 is a BET inhibitor (+)-JQ1 analog with IC50 of 161/20 nM for BRD2/4 respectively.
DDL-357 does not show overt toxicity at concentrations as high as 50 µM in CNS gliotoxicity (U-87 MG), neurotoxicity (SH-SY5Y), nephrotoxicity (HEK 293 T), and hepatotoxicity (HEPG2).
DDL-357 increase sCLU in brain in the ApoE4TR-5XFAD murine model of AD, and both decrease phospho-tau (p-tau) and improve memory in the 3xTg-AD murine model of AD.
DDL-357 increased proteins related to mitochondrial function, synaptic plasticity and protein aggregate clearance in ApoE4TR-5XFAD mice.
DDL-357 increased mitochondrial oxygen consumption, and HN and SirT1 expression in U-87 and SH-SY5Y cells, and neurite outgrowth in iPSC-derived neurons.
Physicochemical Properties
|
M.Wt
|
440.95
|
|
Formula
|
C22H21ClN4O2S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
|
References
1. Cohn W, et al. NPJ Drug Discov. 2025;2(1):7.
Contact Us
sales@probechem.com
