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DLCI-1

Chemical Structure : DLCI-1

CAS No.: 2244569-14-8

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DLCI-1 (CYP2A6 inhibitor DLCI-1)

Catalog No.: PC-49014Not For Human Use, Lab Use Only.

DLCI-1 is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DLCI-1 is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes.
    DLCI-1 exhibit favorable metabolic stability and half-life in human liver microsomes.
    DLCI-1 effectively attenuates intravenous nicotine self-administration in a mouse model.
    DLCI-1 may serve as an effective therapeutic to promote tobacco and nicotine cessation.

    Physicochemical Properties

    M.Wt 218.318
    Formula C12H14N2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine

    References

    1. Yen-Chu Chen, et al. J Pharmacol Exp Ther. 2020 Jan;372(1):21-29.

    2. Denton TT, et al. J Med Chem 61:7065–7086.

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