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Chemical Structure : DO-34
Catalog No.: PC-61837Not For Human Use, Lab Use Only.
DO-34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.
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DO-34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively; shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 and PLA2G7; significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.
| M.Wt | 531.53 | |
| Formula | C26H28F3N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.
2. Deng H, et al. J Med Chem. 2017 Jan 12;60(1):428-440.
3. Wilkerson JL, et al. J Pharmacol Exp Ther. 2017 Oct 2. pii: jpet.117.243808.
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