Chemical Structure : DS-3032
CAS No.: 1398568-47-2
Catalog No.: PC-60302Not For Human Use, Lab Use Only.
Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
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Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
Milademetan (DS-3032) binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.
Milademetan (DS-3032) restores p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
M.Wt | 618.531 | |
Formula | C30H34Cl2FN5O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(3'R,4'S,5'R)-N-((3S,6R)-6-carbamoyltetrahydro-2H-pyran-3-yl)-6''-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide |
1. Ishizawa J, et al. Cancer Res. 2018 May 15;78(10):2721-2731.
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