Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DW-71177
Catalog No.: PC-21651Not For Human Use, Lab Use Only.
DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity.
DW-71177 exhibits KD values of 5.5-13.6 nM for BD1s and 86-163 nM for BD2s in the isothermal titration calorimetry (ITC) experiments.
DW-71177 specifically targets BET bromodomains in bromodomain-selectivity profiling.
DW-71177 exhibits strong growth inhibition (GI50 <0.1 uM) for NUT midline carcinoma cell line (Ty-82), AML cell lines (MV4-11 and THP-1), and B-cell lymphoma cell lines (Pfeiffer and SU-DHL-4).
DW-71177 induces the accumulation of MV4-11 cells in the sub-G1 phase and increases the apoptotic cell population
DW-71177 (120 mg/kg) exhibits antitumor activity in an acute myeloid leukemia (AML) xenograft model.
| M.Wt | 384.48 | |
| Formula | C20H28N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Imran Ali, et al. Eur J Med Chem. 2023 Dec 16:265:116052.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
