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ELOVL1-IN-27

Chemical Structure : ELOVL1-IN-27

CAS No.: 2227482-41-7

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ELOVL1-IN-27

Catalog No.: PC-38655Not For Human Use, Lab Use Only.

ELOVL1-IN-27 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ELOVL1-IN-27 is a highly potent, selective, CNS-penetrant inhibitor of elongation of very long chain fatty acid 1 enzyme (ELOVL1) with IC50 of 13 nM (C26:0 VLCFA inhibition in HEK cell).
ELOVL1-IN-27 selectively inhibits ELOVL1, reducing C26:0 VLCFA synthesis in ALD patient fibroblasts, lymphocytes, and microglia.
ELOVL1-IN-27 reduced C26:0 very long chain fatty acid (VLCFA) concentrations to near-wild-type levels in blood and up to 65% in the brain, a disease-relevant tissue in mouse models of adrenoleukodystrophy (ALD).

Physicochemical Properties

M.Wt 340.334
Formula C18H14F2N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-fluorophenyl)-N-(1-(2-fluoropyridin-4-yl)-1H-pyrazol-3-yl)cyclopropane-1-carboxamide

References

1. Jon H Come, et al. J Med Chem. 2021 Dec 23;64(24):17753-17776.

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