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EX-229

Chemical Structure : EX-229

CAS No.: 1219739-36-2

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EX-229 (EX 229;EX229)

Catalog No.: PC-60179Not For Human Use, Lab Use Only.

EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM.

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10 mg $98 In stock
25 mg $168 In stock
50 mg $268 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM.
EX-229 induces AMPK activation and glucose uptak in a wortmannin-independent manner; increases fatty acid oxidation in L6 myotubes.

Physicochemical Properties

M.Wt 431.876
Formula C24H18ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid

References

1. Lai YC, et al. Biochem J. 2014 Jun 15;460(3):363-75.

2. Bultot L, et al. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719.

3. Patent WO2010036613, EX229.

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