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Chemical Structure : F-11440
CAS No.: 179756-58-2
Catalog No.: PC-45757Not For Human Use, Lab Use Only.
A potent, selective 5-HT1A receptor agonist with Ki of 4.8 nM, pKi of 8.33.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A potent, selective 5-HT1A receptor agonist with Ki of 4.8 nM, pKi of 8.33; shows ≥shows 100-fold higher affinity for the other serotonin receptor subtypes, and has no detectable antidopaminergic activity and antihistaminergic activity; decreases the forskolin-induced increase in AMP in HeLa cells expressing human 5-HT1A receptors; produces anxiolytic- and antidepressant-like effects in animal models.
Anxiety
Phase 1 Discontinued
| M.Wt | 345.3995 | |
| Formula | C16H23N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]- |
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1. Koek W, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):266-83.
2. Prinssen EP, et al. Eur J Pharmacol. 2002 Oct 25;453(2-3):217-21.
3. Pauwels PJ, et al. J Pharmacol Exp Ther. 2003 Nov;307(2):608-14.
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