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FAAH-IN-2

Chemical Structure : FAAH-IN-2

CAS No.: 1361993-03-4

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FAAH-IN-2

Catalog No.: PC-70218Not For Human Use, Lab Use Only.

FAAH-IN-2 is a potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FAAH-IN-2 is a potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH.
    FAAH-IN-2 demonstrates an excellent selectivity profile against a panel of cannabinoid related targets, including CB1, CB2, and VR1.
    FAAH-IN-2 demonstrates a unique nonmechanism-based inhibition of FAAH activity, which is distinct from almost all known FAAH inhibitors.
    FAAH-IN-2 shows excellent PK properties with a low clearance of 0.4 L/h/Kg and a high bioavailability of 92%.

    Physicochemical Properties

    M.Wt 421.266
    Formula C19H18BrFN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-bromo-N-(2-fluorophenyl)-4H-spiro[benzo[d][1,3]dioxine-2,4'-piperidine]-1'-carboxamide

    References

    1. Min X, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84.

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