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FHD-286

Chemical Structure : FHD-286

CAS No.: 2671128-05-3

FHD-286 (FHD286)

Catalog No.: PC-73320Not For Human Use, Lab Use Only.

FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.
FHD-286 is a novel BAF (BAF (BRG1/BRM-Associated Factor) inhibitor for the treatment of acute myeloid leukemia (AML), Myelodysplastic syndromes (MDS) and metastatic uveal melanoma (UM).

Physicochemical Properties

M.Wt 562.660
Formula C24H30N6O6S2
CAS No. 2671128-05-3
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name

N-((S)-1-((4-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide

References

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