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Chemical Structure : FHD-286
CAS No.: 2671128-05-3
Catalog No.: PC-73320Not For Human Use, Lab Use Only.
FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $478 | In stock | |
| 25 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.
FHD-286 is a novel BAF (BAF (BRG1/BRM-Associated Factor) inhibitor for the treatment of acute myeloid leukemia (AML), Myelodysplastic syndromes (MDS) and metastatic uveal melanoma (UM).
| M.Wt | 562.660 | |
| Formula | C24H30N6O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-1-((4-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide |
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1. Warren C. Fiskus, et al. Cancer Res (2023) 83 (7_Supplement): 1140.
2. Fiskus W, et al. Blood. 2024 May 16;143(20):2059-2072.
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