Catalog No.: PC-73320Not For Human Use, Lab Use Only.
Camibirstat (FHD-286) is a highly potent, selective, allosteric and orally available inhibitor of BRM (SMARCA2) and BRG1 (SMARCA4) ATPase subunits with IC50 of 4.5 nM and 6.5 nM, respectively.
Camibirstat (FHD-286) is a highly potent, selective, allosteric and orally available inhibitor of BRM (SMARCA2) and BRG1 (SMARCA4) ATPase subunits with IC50 of 4.5 nM and 6.5 nM, respectively.
FHD-286 showed low nanomolar activity in cellular MMTV luciferase assays and potent antitumor activity against the uveal melanoma 92-1 cell line both in vitro and in vivo in a mouse xenograft model.
FHD-286 has shown antiproliferative activity in xenograft models of non-small-cell lung cancer and prostate cancer.
FHD-286 has also been reported to resensitize TKI-resistant lung cancer to an EGFR inhibitor and tumor growth inhibition was observed when the two inhibitors were treated in combination in a patient-derived mouse xenograft model.
