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FHD-286

Chemical Structure : FHD-286

CAS No.: 2671128-05-3

FHD-286 (FHD286)

Catalog No.: PC-73320Not For Human Use, Lab Use Only.

FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor.
FHD-286 is a novel BAF (BAF (BRG1/BRM-Associated Factor) inhibitor for the treatment of acute myeloid leukemia (AML), Myelodysplastic syndromes (MDS) and metastatic uveal melanoma (UM).

Physicochemical Properties

M.Wt 562.660
Formula C24H30N6O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((S)-1-((4-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide

References

1. Warren C. Fiskus, et al. Cancer Res (2023) 83 (7_Supplement): 1140.
2. Fiskus W, et al. Blood. 2024 May 16;143(20):2059-2072.

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