FKBP12 PROTAC dTAG-7 |CAS:2064175-32-0 Probechem Biochemicals

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Chemical Structure : FKBP12 PROTAC dTAG-7

CAS No.: 2064175-32-0

FKBP12 PROTAC dTAG-7 (dTAG-7)

Catalog No.: PC-35858Not For Human Use, Lab Use Only.

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
dTAG-7 causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras.

Physicochemical Properties

M.Wt	1210.341
Formula	C63H79N5O19
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

References

1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441.

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FKBP12 PROTAC dTAG-7 (dTAG-7)

Biological Activity

Physicochemical Properties

References

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