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FLLL-32

Chemical Structure : FLLL-32

CAS No.: 1226895-15-3

FLLL-32 (JAK2 Inhibitor X;FLLL32)

Catalog No.: PC-61668Not For Human Use, Lab Use Only.

FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM); induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.

Physicochemical Properties

M.Wt 464.6
Formula C28H32O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one

References

1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.

2. Bill MA, et al. Mol Cancer. 2010 Jun 25;9:165.

3. Fossey SL, et al. BMC Cancer. 2011 Mar 28;11:112.

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