FRAX1036 is a potent and selective inhibitor of group I PAKs (PAK1, Ki=23.3 nM; PAK2, Ki=72.4 nM).
FRAX1036 displays weak affinity on PAK4 (Ki = 2.4 uM).
FRAX1036 inhibits phosphorylation of MEK1-S298 and CRAF-S338 at 2.5-5 uM in MDA-MB-175 cells.
FRAX1036 inhibits MPNST cell growth in vitro and dramatically decreases local and metastatic MPNST growth in animal models combined with PD0325901.
