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Chemical Structure : Fusicoccin-A
CAS No.: 20108-30-9
Catalog No.: PC-61233Not For Human Use, Lab Use Only.
Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
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Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Fusicoccin-A induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo.
Fusicoccin-A stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).
| M.Wt | 680.82 | |
| Formula | C36H56O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propenyl)-, 3-acetate (9CI) |
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1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.
2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.
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