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Chemical Structure : G-1
CAS No.: 881639-98-1
Catalog No.: PC-60270Not For Human Use, Lab Use Only.
GPER/GPR30 agonist G-1 (Tespria) is potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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GPER/GPR30 agonist G-1 (Tespria) is potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM.
GPER/GPR30 agonist G-1 displays no activity at ERα and ERβ at concentrations up to 10 uM.
GPER/GPR30 agonist G-1 increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 of 0.7 and 1.6 nM respectively.
GPER/GPR30 agonist G-1 induces cell cycle arrest, DNA damage and cell death by the activation of the intrinsic apoptotic mechanism in H295R cells.
| M.Wt | 412.28 | |
| Formula | C21H18BrNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone |
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1. Wang C, et al. Mol Endocrinol. 2008 Mar;22(3):636-48.
2. Chimento A, et al. Oncotarget. 2015 Aug 7;6(22):19190-203.
3. Ahola TM, et al. Endocrinology. 2002 Sep;143(9):3376-84.
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