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Chemical Structure : G-15
Catalog No.: PC-60268Not For Human Use, Lab Use Only.
G-15 (GPR30 inhibitor G15, G15) is a potent, selective GPER/GPR30 antagonist with Ki of 20 nM.
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G-15 (GPR30 inhibitor G15, G15) is a potent, selective GPER/GPR30 antagonist with Ki of 20 nM; displays little binding affinity to ERα or ERβ at 10 uM; inhibits the G-1-mediated activation of PI3K, also effectively blocks the estrogen-mediated response in GPR30-transfected cells; also blocks G-1-induced proliferation in the ovariectomized mouse model.
| M.Wt | 370.24 | |
| Formula | C19H16BrNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dennis MK, et al. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66.
2. Dennis MK, et al. Nat Chem Biol. 2009 Jun;5(6):421-7.
3. Sharma G, et al. Endocrinology. 2011 Aug;152(8):3030-9.
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