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Chemical Structure : G-36
Catalog No.: PC-60269Not For Human Use, Lab Use Only.
A potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively.
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A potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively; has no detectable binding activity to either ERα or Erβ; inhibits estrogen- and G-1-mediated calcium mobilization as well as ERK1/2 activation, with no effect on EGF-mediated ERK1/2 activation.
| M.Wt | 412.3 | |
| Formula | C22H22BrNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dennis MK, et al. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66.
2. Ashton AW, et al. Mol Endocrinol. 2015 Aug;29(8):1144-55.
3. Evans NJ, et al. PLoS One. 2016 Mar 21;11(3):e0152138.
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