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Chemical Structure : GCGR-IN-17
CAS No.: 1393124-08-7
Catalog No.: PC-45758Not For Human Use, Lab Use Only.
PF06291874 (GCGR-IN-17) is a highly potent glucagon receptor antagonist with Ki of 14 nM for hGCGR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | $898 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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PF06291874 (GCGR-IN-17) is a highly potent glucagon receptor antagonist with Ki of 14 nM for hGCGR.
PF06291874 shows excellent selectivity against a panel of 69 receptors, ion channels, uptake sites and enzymes.
PF06291874 reduces the glucagon-elicited glucose excursion in a dose-dep endent manner in rats.
PF06291874 displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.
| M.Wt | 503.5134 | |
| Formula | C26H28F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
glucagon receptor antagonists-4, N-[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy]butyl]benzoyl]- |
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1. Guzman-Perez A, et la. Bioorg Med Chem Lett. 2013 May 15;23(10):3051-8.
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