You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-GFH009
GFH009

Chemical Structure : GFH009

CAS No.: 2247481-08-7

GFH009 (GFH 009)

Catalog No.: PC-21562Not For Human Use, Lab Use Only.

GFH009 is a potent, highly selective CDK9 inhibitor with IC50 of 9 nM against CDK9/Cyclin T1 complex, blocks RNAP2-mediated transcription maturation.

Packing Price Stock Quantity
2 mg $298 In stock
5 mg $498 In stock
10 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: 99.9% (HPLC) Select Batch:

Biological Activity

GFH009 is a potent, highly selective CDK9 inhibitor with IC50 of 9 nM against CDK9/Cyclin T1 complex, blocks RNAP2-mediated transcription maturation.
shows negligible effects on other CDK family members
GFH009 demonstrates effective antiproliferative activity in a variety of human hematologic malignancy cell lines, with IC50 values below 0.2 μM in 7 of the 10 lines tested.
GFH009 demonstrates significant reduction of MCL-1 and proto-oncogene c-Myc, increases apoptosis markers Cleaved caspase-3 and Cleaved PARP in MV-4-11 cell cultures.
GFH009 (2.5 mg/kg-10 mg/kg, i.v.) exhibits tumor growth inhibition in MV-4-11 xenograft in female BALB/c nude mice.

Physicochemical Properties

M.Wt 519.11
Formula C25H35ClN6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[[[4-[5-Chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

References

1. Zhou F, et al. Oncotarget. 2023 Dec 20;14:997-1008.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: