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Chemical Structure : GLPG3667
Catalog No.: PC-22404Not For Human Use, Lab Use Only.
GLPG3667 is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
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GLPG3667 is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
GLPG3667 is a selective TYK2 inhibitor in human PBMC and whole blood assays.
GLPG3667 shows dose-dependent inhibition of IFNα-induced STAT1 phosphorylation (JAK1/TYK2-dependent, IC50=70 nM), IL-2-induced STAT5 phosphorylation (JAK1/JAK3-dependent) and granulocyte macrophage colony-stimulating factor (GM-CSF)-induced STAT5 phosphorylation (JAK2-dependent).
GLPG3667 displays general kinase selectivity against a panel of 365 kinases.
GLPG3667 reduced dermal ear inflammation in an IL-23-induced in vivo mouse model of psoriasis.
| M.Wt | 443.47 | |
| Formula | C22H21N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mammoliti O, et al. J Med Chem. 2024 May 28. doi: 10.1021/acs.jmedchem.4c00769.
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