Chemical Structure : GLPG3667
CAS No.:
2308520-97-8
GLPG3667
(GLPG 3667, GLPG-3667)
Catalog No.: PC-22404Not For Human Use, Lab Use Only.
GLPG3667 is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GLPG3667 is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
GLPG3667 is a selective TYK2 inhibitor in human PBMC and whole blood assays.
GLPG3667 shows dose-dependent inhibition of IFNα-induced STAT1 phosphorylation (JAK1/TYK2-dependent, IC50=70 nM), IL-2-induced STAT5 phosphorylation (JAK1/JAK3-dependent) and granulocyte macrophage colony-stimulating factor (GM-CSF)-induced STAT5 phosphorylation (JAK2-dependent).
GLPG3667 displays general kinase selectivity against a panel of 365 kinases.
GLPG3667 reduced dermal ear inflammation in an IL-23-induced in vivo mouse model of psoriasis.
Physicochemical Properties
|
M.Wt
|
443.47
|
|
Formula
|
C22H21N9O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-methyl-5-((3-methyl-7-((6-morpholinopyridazin-3-yl)amino)-3H-imidazo[4,5-b]pyridin-5-yl)oxy)picolinonitrile
|
References
1. Mammoliti O, et al. J Med Chem. 2024 May 28. doi: 10.1021/acs.jmedchem.4c00769.
Contact Us
sales@probechem.com
