Chemical Structure : GLPG3667
CAS No.: 2308520-97-8
Catalog No.: PC-22404Not For Human Use, Lab Use Only.
Cadefrecitinib (GLPG3667) is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $178 | In stock | |
10 mg | $288 | In stock | |
25 mg | $488 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Cadefrecitinib (GLPG3667) is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM.
GLPG3667 is a selective TYK2 inhibitor in human PBMC and whole blood assays.
GLPG3667 shows dose-dependent inhibition of IFNα-induced STAT1 phosphorylation (JAK1/TYK2-dependent, IC50=70 nM), IL-2-induced STAT5 phosphorylation (JAK1/JAK3-dependent) and granulocyte macrophage colony-stimulating factor (GM-CSF)-induced STAT5 phosphorylation (JAK2-dependent).
GLPG3667 displays general kinase selectivity against a panel of 365 kinases.
GLPG3667 reduced dermal ear inflammation in an IL-23-induced in vivo mouse model of psoriasis.
M.Wt | 443.47 | |
Formula | C22H21N9O2 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
4-methyl-5-((3-methyl-7-((6-morpholinopyridazin-3-yl)amino)-3H-imidazo[4,5-b]pyridin-5-yl)oxy)picolinonitrile |
1. Mammoliti O, et al. J Med Chem. 2024 May 28. doi: 10.1021/acs.jmedchem.4c00769.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright