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GNF-6702

Chemical Structure : GNF-6702

CAS No.: 1799329-72-8

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GNF-6702 (GNF 6702;GNF6702)

Catalog No.: PC-60315Not For Human Use, Lab Use Only.

GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections.

Physicochemical Properties

M.Wt 429.406
Formula C22H16FN7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[4-fluoro-3-(6-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide

References

1. Khare S, et al. Nature. 2016 Sep 8;537(7619):229-233.

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