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Chemical Structure : GS-5734
CAS No.: 1809249-37-3
Catalog No.: PC-60313Not For Human Use, Lab Use Only.
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $568 | In stock | |
| 100 mg | $958 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
GS-5734 (Remdesivir) suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.
GS-5734 (Remdesivir) is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
| M.Wt | 601.597 | |
| Formula | C28H36N5O8P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
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1. Warren TK, et al. Nature. 2016 Mar 17;531(7594):381-5.
2. Jacobs M, et al. Lancet. 2016 Jul 30;388(10043):498-503.
3. Siegel D, et al. J Med Chem. 2017 Mar 9;60(5):1648-1661.
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