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GSK-1322322

Chemical Structure : GSK-1322322

CAS No.: 1152107-25-9

GSK-1322322 (Lanopepden;GSK-322)

Catalog No.: PC-70018Not For Human Use, Lab Use Only.

A novel antibacterial agent that targets bacterial peptide deformylase.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel antibacterial agent that targets bacterial peptide deformylase; demonstrates in vitro activity against MDR respiratory and skin infection pathogens, including MDR Streptococcus pneumoniae and MRSA; inhibits S. pneumoniae ATCC 49619 with MIC of 0.12-0.5 ug/mL.

Physicochemical Properties

M.Wt 479.56
Formula C22H34FN7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N-hydroxyformamide

References

1. Ross JE, et al. J Clin Microbiol. 2011 Nov;49(11):3928-30.

2. Arat S, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92.

3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2013 May;57(5):2333-42.

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