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Chemical Structure : GSK-2606414
CAS No.: 1337531-36-8
Catalog No.: PC-45410Not For Human Use, Lab Use Only.
GSK-2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GSK-2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
GSK-2606414 inhibits PERK activation in cells and inhibits the growth of human tumor xenograft in mice.
GSK-2606414 reduces p-eIF2α levels and enhanced novel taste learning and conditioned taste aversion, but not memory retrieval in rats.
| M.Wt | 451.4437 | |
| Formula | C24H20F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]- |
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1. Axten JM, et al. J Med Chem. 2012 Aug 23;55(16):7193-207.
2. Ounallah-Saad H, et al. J Neurosci. 2014 Oct 29;34(44):14624-32.
3. Guthrie LN, et al. J Biol Chem. 2016 Jul 22;291(30):15830-40.
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