Chemical Structure : GSK-467
CAS No.: 1628332-52-4
Catalog No.: PC-62292Not For Human Use, Lab Use Only.
GSK-467 is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.
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GSK-467 (GSK467) is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.
GSK-467 (GSK467) increases the rate of apoptosis in myeloma cells.
M.Wt | 319.32 | |
Formula | C17H13N5O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-[(1-Benzyl-1H-pyrazol-4-yl)oxy]-pyrido-[3,4-d]pyrimidin-4(3H)-one |
1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.
2. Westaway SM, et al. J Med Chem. 2016 Feb 25;59(4):1370-87.
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