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Chemical Structure : GSK1070916
CAS No.: 942918-07-2
Catalog No.: PC-45943Not For Human Use, Lab Use Only.
GSK1070916 is a potent, selective and ATP-competitive inhibitor of Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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GSK1070916 is a potent, selective and ATP-competitive inhibitor of Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM, respectively.
GSK1070916 displays >250-fold selectivity over Aurora A; shows potent antiproliferative effect (EC50=7 nM) in A549 human lung cancer cells.
GSK1070916 causes inhibition of histone H3 phosphorylation at serine 10 in human colon cancer (Colo205) and tumor regression in human leukemia (HL-60) in mice.
| M.Wt | 507.6293 | |
| Formula | C30H33N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 26.5 mg/mL |
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| Chemical Name/SMILES |
Urea, N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl- |
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1. Adams ND, et al. J Med Chem. 2010 May 27;53(10):3973-4001.
2. Hardwicke MA, et al. Mol Cancer Ther. 2009 Jul;8(7):1808-17.
3. Moy C, et al. J Transl Med. 2011 Jul 15;9:110.
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