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GST-HG121

Chemical Structure : GST-HG121

CAS No.: 2270215-69-3

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GST-HG121

Catalog No.: PC-49333Not For Human Use, Lab Use Only.

GST-HG131 is a specific small molecule HBV antigen inhibitor, exhibits excellent and specific HBV antigens inhibition with EC50 of 28.2 nM (HBsAg) and 16.0 nM (HBeAg), respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GST-HG131 is a specific small molecule HBV antigen inhibitor, exhibits excellent and specific HBV antigens inhibition with EC50 of 28.2 nM (HBsAg) and 16.0 nM (HBeAg), respectively.
GST-HG131 shows antiviral activity in primary human hepatocytes (PHH) expressing HBV, inhibits HBV antigens (both HBsAg and HBeAg).
GST-HG131 (500 nM) inhibits HBV antigens through inhibition of HBV RNAs in a dose- and time-dependent manner.
GST-HG131 shows specific HBV inhibition over other viruses, such as hepatitis C virus, herpes simplex virus type 1 and influenza virus H1N1.
GST-HG131 (3, 10, and 30 mg/kg; i.v., tail vein injection; once daily for 4 weeks) shows HBV inhibition in an AAV/HBV mouse model.

Physicochemical Properties

M.Wt 431.485
Formula C23H29NO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-7-(tert-butyl)-2-methoxy-3-(3-methoxypropoxy)-11-oxo-6,7-dihydro-11H-benzo[f]pyrido[1,2-d][1,4]oxazepine-10-carboxylic acid

References

1. Hu Y, et al. Bioorg Med Chem Lett. 2022 Nov 1;75:128977.

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