Catalog No.: PC-26472Not For Human Use, Lab Use Only.
GW833972A is a potent, selective CB2 receptor agonist with pEC50 of 7.3 and 7.5 for human and rat CB2 receptors respecitvely, shows 1000-fold selectivity over CB1 receptor, also binds BMAL2 with high affinity and facilitates its protein degradation.
GW833972A is a potent, selective CB2 receptor agonist with pEC50 of 7.3 and 7.5 for human and rat CB2 receptors respecitvely, shows 1000-fold selectivity over CB1 receptor, also binds BMAL2 with high affinity and facilitates its protein degradation. GW833972A (0.3-300 uM) induced a concentration-dependent inhibition of the guinea-pig vagus nerve activity, stimulated by either capsaicin, hypertonic saline or PGE2. GW833972A abolished Capsaicin-induced depolarizations at 300 μM with EC50 of 33.9 uM. GW833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB2 receptor antagonist. GW833972A reduced RAD51 expression, leading to an accumulation of DNA damage, decreased cell viability and reduced OCCC tumor growth. GW833972A enhanced the effectiveness of Poly (ADP-ribose) polymerase inhibitor (PARPi) treatments in BMAL2-expressing OCCC.
