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Chemical Structure : HBX-19818
CAS No.: 1426944-49-1
Catalog No.: PC-45339Not For Human Use, Lab Use Only.
HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
HBX-19818 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
HBX-19818 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
| M.Wt | 421.96 | |
| Formula | C25H28ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (Ultrasonic Needed) |
|
| Chemical Name/SMILES |
2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]- |
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1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
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