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HBX-19818

Chemical Structure : HBX-19818

CAS No.: 1426944-49-1

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HBX-19818 (HBX19818)

Catalog No.: PC-45339Not For Human Use, Lab Use Only.

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.

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5 mg $158 In stock
10 mg $248 In stock
25 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
HBX-19818 exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1.
HBX-19818 reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.

Physicochemical Properties

M.Wt 421.96
Formula C25H28ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (Ultrasonic Needed)
Chemical Name/SMILES

2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

References

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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